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S Jongen 1 , A Vermeeren 2 , N N J J M van der Sluiszen 2 , M B Schumacher 3 , E L Theunissen 2 , K P C Kuypers 2 , E F P M Vuurman 2 , J G Ramaekers 2 Affiliations 1 Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Universiteitssingel 40, 6200 MD, Maastricht, The Netherlands.
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van der Sluiszen N, Vermeeren A, Jongen S, Theunissen E, van Oers A, Van Leeuwen C, et al. On-the-road driving performance after use of the antihistamines mequitazine and l-mequitazine, alone and with alcohol. Psychopharmacology. 2016; 233 (18):3461-3469. doi: 10.1007/s00213-016-4386-7.
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2of13 VAN DER SLUISZEN ET AL. Declaration of Helsinki (1964), amended in Edinburgh (2000), Seoul (2008), and Fortaleza (2013). Written informed consent was obtained from each volunteer before enrolment. Volunteers received a financial compensation for their participation in the study.
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An explorative approach to understanding individual differences in driving performance and neurocognition in long‐term benzodiazepine users
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The role of acute intoxication and clinical complaints in long‐term users of benzodiazepine receptor agonists is explored. Previous research reported cognitive and psychomotor impairments in long‐term users of benzodiazepine receptor agonists (BZRAs). This article explores the role of acute intoxication and clinical complaints.
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The calculation of the SDLP is described in (van der Sluiszen et al., 2021). Most previous studies involving SDLP were designed to evaluate the influence of drugs or alcohol on driving performance, using a threshold of a 2.5‐cm increase in SDLP as an indication of clinically relevant driving impairment.
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Figure and description taken with permission from van der Sluiszen et al. Drug-induced impairments in the standardised highway driving test have been compared to that of a well-known benchmark drug (i.e., alcohol) that is known to jeopardise traffic safety and shows a clear exponential dose-dependent relationship with accident crash risk.
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van der Sluiszen N, Vermeeren A, Verster JC, et al. Driving performance and neurocognitive skills of long-term users of benzodiazepine anxiolytics and hypnotics. Hum Psychopharmacol. 2019;34:e2715. CrossRef PubMed PubMed Central CAS Google Scholar van der Sluiszen N, Vermeeren A, van Dijken JH, et al. Driving performance and neurocognitive.
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Charles Michel waited until January 7. The president of the European Council — which brings together the leaders of EU member countries — announced he will run as a candidate in the European parliamentary election in June. If he's elected, he would take up his seat in July, well before his term is scheduled to end in November.
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@article{vanderSluiszen2020DrivingPA, title={Driving performance and neurocognitive skills of long‐term users of sedating antidepressants}, author={Nick N J J M van der Sluiszen and Annemiek Vermeeren and Joke H van Dijken and Aurora J A E van de Loo and Janet L Veldstra and D. de Waard and Joris C Verster and Karel A Brookhuis and Johannes G.
Driving performance and neurocognitive skills of long‐term users of sedating antidepressants
A recent study by van der Sluiszen et al. on neurocognitive and driving performance of long‐term (≥6 months) BZRA users found that this group exhibited significant impairments on tasks of vigilance, executive functioning, and reaction speed. In line with these findings, a meta‐analysis by Barker, Greenwood.
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The present data were collected as part of a larger study on the long‐term effects of benzodiazepines and antidepressants on driving performance. Data on long‐term benzodiazepine use and driving are published separately (van der Sluiszen et al., 2019).
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This finding seems in line with recent reviews (Crowe & Stranks, 2017; van der Sluiszen, Vermeeren, Jongen, Vinckenbosch, & Ramaekers, 2017) concluding that long‐term treatment with benzodiazepines can be associated with deleterious neuropsychological effects.
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2 of 12-van der sluiszen et al. screening was based on a medical history questionnaire evaluated by research physicians (MDs) responsible for the medical well‐being
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van der Sluiszen et al. (2019) pointed out the problem of heteroge-neity of medication use that is inherent to a clinical sample of BZRA users. The patients included in the study used different BZRAs (i.e., different potencies), at different doses, at different frequencies, and at different times relative to the laboratory tests and on‐road.